CLUSTAL W 2.0 multiple sequence alignment 2_Mus_musculus -------------------------------------------------- 3_Homo_sapiens CCGTCCGTCCGTCGTCCTCCTCGCTTGCGGGGCGCCGGGCCCGTCCTCGA 4_Gallus_gallus -------------------------------------------------- 1_Ornithorhynchus_anatinus -------------------------------------------------- 2_Mus_musculus -------------------------------------------------- 3_Homo_sapiens GCCCCCNNNNNCCGTCCGGCCGCGTCGGGGCCTCGCCGCGCTCTACCTAC 4_Gallus_gallus -------------------------------------------------- 1_Ornithorhynchus_anatinus -------------------------------------------------- 2_Mus_musculus -TACCTGGTTGATCCTGCCAGTAGCATATGCTTGTCTCAAAGATTAAGCC 3_Homo_sapiens CTACCTGGTTGATCCTGCCAGTAGCATATGCTTGTCTCAAAGATTAAGCC 4_Gallus_gallus ------------------------------------------ATTAAGCC 1_Ornithorhynchus_anatinus ----------------------AGCATATGCTTGTCTCAAAGATTAAGCC ******** 2_Mus_musculus ATGCATGTCTAAGTACGCACGGCCGGTACAGTGAAACTGCGAATGGCTCA 3_Homo_sapiens ATGCATGTCTAAGTACGCACGGCCGGTACAGTGAAACTGCGAATGGCTCA 4_Gallus_gallus ATGCATGTCTAAGTACACACGGGCGGTACAGTGAAACTGCGAATGGCTCA 1_Ornithorhynchus_anatinus ATGCATGTCTAAGTACACACGGCCGGCACAGTGAAACTGCGAATGGCTCA **************** ***** *** *********************** 2_Mus_musculus TTAAATCAGTTATGGTTCCTTTGGTCGCTCGCTCCTCTCCTACTTGGATA 3_Homo_sapiens TTAAATCAGTTATGGTTCCTTTGGTCGCTCGCTCCTCTCCTACTTGGATA 4_Gallus_gallus TTAAATCAGTTATGGTTCCTTTGGTCGCTC-CCCTCCCGTTACTTGGATA 1_Ornithorhynchus_anatinus TTAAATCAGTTATGGTTCCTTTGGTCGCTCGCTCC-CTCCTACTTGGATA ****************************** * * * ********** 2_Mus_musculus ACTGTGGTAATTCTAGAGCTAATACATGCCGACGGGCGCTGACCC----- 3_Homo_sapiens ACTGTGGTAATTCTAGAGCTAATACATGCCGACGGGCGCTGACCC----- 4_Gallus_gallus ACTGTGGTAATTCTAGAGCTAATACATGCCGACGAGCGCCGACCT----- 1_Ornithorhynchus_anatinus ACTGTGGTAATTCTAGAGCTAATACATGCCGACGAGCGCTGACCCGGGCC ********************************** **** **** 2_Mus_musculus ----CCCTTCCCGGGG----------GGGGATGCGTGCATTTATCAGATC 3_Homo_sapiens ----CCTTCGC--GGG----------GGGGATGCGTGCATTTATCAGATC 4_Gallus_gallus ----CC--------------------GGGGACGCGTGCATTTATCAGACC 1_Ornithorhynchus_anatinus CCTTTCCCCCCGTGGGTGGGGGCTCCGGGGATGCGTGCATTTATCAGACC * ***** **************** * 2_Mus_musculus AAAACCAACCCGGTGAGCTCCCTCCCGGCTCCGGCCGGGGGTCGGG---- 3_Homo_sapiens AAAACCAACCCGGTCAGCCCCTCTCCGGCCCCGGCCGGGGGGCGGG---- 4_Gallus_gallus AAAACCAACCCGG---GCTCGCC--------------------------- 1_Ornithorhynchus_anatinus AAAACCAACCCGGCGGTTTCCCCCCAACCCCCCAACCAGGGGCGGGGGTG ************* * 2_Mus_musculus CGCCGGCGGCTT-GGTGACTCTAGATAACCTCGGGCCGATCGCACGCCCC 3_Homo_sapiens CCGCGGCGGCTTTGGTGACTCTAGATAACCTCGGGCCGATCGCACGCCCC 4_Gallus_gallus ---CGGCGGCTTTGGTGACTCTAGATAACCTCGAGCCGATCGCACGCCCC 1_Ornithorhynchus_anatinus CCCCGGCCGCTTTGGTGACTCTAGATAACCTCGGGCCGATCGCACGCCCC **** **** ******************** **************** 2_Mus_musculus CCGTGGCGGCGACGACCCATTCGAACGTCTGCCCTATCAACTTTCGATGG 3_Homo_sapiens CCGTGGCGGCGACGACCCATTCGAACGTCTGCCCTATCAACTTTCGATGG 4_Gallus_gallus C-GTGGCGGCGACGACCCATTCGAATGTCTGCCCTATCAACTTTCGATGG 1_Ornithorhynchus_anatinus CCGTGGCGGCGATGACCCATTCGAACGTCTGCCCTATCAACTTTCGATGG * ********** ************ ************************ 2_Mus_musculus TAGTCGCCGTGCCTACCATGGTGACCACGGGTGACGGGGAATCAGGGTTC 3_Homo_sapiens TAGTCGCCGTGCCTACCATGGTGACCACGGGTGACGGGGAATCAGGGTTC 4_Gallus_gallus TACTGTCTGTGCCTACCATGGTGACCACGGGTAACGGGGAATCAGGGTTC 1_Ornithorhynchus_anatinus TACTTGCCGTGCCTACCATGGTGACCACGGGTGACGGGGAATCAGGGTTC ** * * ************************ ***************** 2_Mus_musculus GATTCCGGAGAGGGAGCCTGAGAAACGGCTACCACATCCAAGGAAGGCAG 3_Homo_sapiens GATTCCGGAGAGGGAGCCTGAGAAACGGCTACCACATCCAAGGAAGGCAG 4_Gallus_gallus GATTCCGGAGAGGGAGCCTGAGAAACGGCTACCACATCCAAGGAAGGCAG 1_Ornithorhynchus_anatinus GATTCCGGAGAGGGAGCCTGAGAAACGGCTACCACATCCAAGGAAGGCAG ************************************************** 2_Mus_musculus CAGGCGCGCAAATTACCCACTCCCGACCCGGGGAGGTAGTGACGAAAAAT 3_Homo_sapiens CAGGCGCGCAAATTACCCACTCCCGACCCGGGGAGGTAGTGACGAAAAAT 4_Gallus_gallus CAGGCGCGCAAATTACCCACTCCCGACCCGGGGAGGTAGTGACGAAAAAT 1_Ornithorhynchus_anatinus CAGGCGCGCAAATTACCCACTCCCGACCCGGGGAGGTAGTGACGAAAAAT ************************************************** 2_Mus_musculus AACAATACAGGACTCTTTCGAGGCCCTGTAATTGGAATGAGTCCACTTTA 3_Homo_sapiens AACAATACAGGACTCTTTCGAGGCCCTGTAATTGGAATGAGTCCACTTTA 4_Gallus_gallus AACAATACAGGACTCTTTCGAGGCCCTGTAATTGGAATGAGTCCACTTTA 1_Ornithorhynchus_anatinus AACAATACAGGACTCTTTCGAGGCCCTGTAATTGGAATGAGCACACTTTA ***************************************** ******* 2_Mus_musculus AATCCTTTA-ACGAGGATCCATTGGAGGGCAAGTCTGGTGCCAGCAGCCG 3_Homo_sapiens AATCCTTTA-ACGAGGATCCATTGGAGGGCAAGTCTGGTGCCAGCAGCCG 4_Gallus_gallus AATCCTTTA-ACGAGGATCCATTGGAGGGCAAGTCTGGTGCCAGCAGCCG 1_Ornithorhynchus_anatinus AATCCTTTTCGCGAGGATCCATTGGAGGGCAAGTCTGGTGCCAGCAGCCG ******** *************************************** 2_Mus_musculus CGGTAATTCCAGCTCCAATAGCGTATATTAAAGTTGCTGCAGTTAAAAAG 3_Homo_sapiens CGGTAATTCCAGCTCCAATAGCGTATATTAAAGTTGCTGCAGTTAAAAAG 4_Gallus_gallus CGGTAATTCCAGCTCCAATAGCGTATATTAAAGTTGCTGCAGTTAAAAAG 1_Ornithorhynchus_anatinus CGGTAATTCCAGCTCCAATAGCGTATCTTAAAGTTGCTGCAGTTAAAAAG ************************** *********************** 2_Mus_musculus CTCGTAGTTGGATCTTGGGAGCGGGCGGGCGGTCCGCCGCGAGGCGAGTC 3_Homo_sapiens CTCGTAGTTGGATCTTGGGAGCGGGCGGGCGGTCCGCCGCGAGGCGAGCC 4_Gallus_gallus CTCGTAGTTGGATCTTGGGATCGAGCTGGCGGTCCGCCGCGAGGCGAGCT 1_Ornithorhynchus_anatinus CTCGTAGTTGGATCTTGGGATCGAGCTGGCGGTCCGCCGCGAGGCGAGCC ******************** ** ** ********************* 2_Mus_musculus ACCGCCCGTCCCCGCCCCTTGCCTCTCGGCGCCCCCTCGATGCTCTTAGC 3_Homo_sapiens ACCGCCCGTCCCCGCCCCTTGCCTCTCGGCGCCCCCTCGATGCTCTTAGC 4_Gallus_gallus ACCGCCTGTCCCAGCCCCT-GTCTCTCGGCGCCCCCTCGATGCTCTTAAC 1_Ornithorhynchus_anatinus ACCGCCTGTCCCCGCCCCTGCCCTCTCGGCGCCCCCTCGATGCTCTTAGC ****** ***** ****** ************************** * 2_Mus_musculus TGAGTGTCCCGCGGGGCCCGAAGCGTTTACTTTGAAAAAATTAGAGTGTT 3_Homo_sapiens TGAGTGTCCCGCGGGGCCCGAAGCGTTTACTTTGAAAAAATTAGAGTGTT 4_Gallus_gallus TGAGTGTCCCGCGGGGCCCGAAGCGTTTACTTTGAAAAAATTAGAGTGTT 1_Ornithorhynchus_anatinus TGAGTGTCCCGCGGGGCCCGAAGCGTTTACTTTGAAAAAATTAGAGTGTT ************************************************** 2_Mus_musculus CAAAGCAGGCCCGAGCCGCCTGGATACCGCAGCTAGGAATAATGGAATAG 3_Homo_sapiens CAAAGCAGGCCCGAGCCGCCTGGATACCGCAGCTAGGAATAATGGAATAG 4_Gallus_gallus CAAAGCAGGCT--GGCCGCCGGAATACTCCAGCTAGGAATAATGGAATAG 1_Ornithorhynchus_anatinus CAAAGCAGGCCC-GGTCGCCTGGATACTCCAGCTAGGAATGATGGAATAG ********** * **** * **** *********** ********* 2_Mus_musculus GACCGCGGT-TCTATTTTGTTGGTTTTCGGAACTGAGGCCATGATTAAGA 3_Homo_sapiens GACCGCGGT-TCTATTTTGTTGGTTTTCGGAACTGAGGCCATGATTAAGA 4_Gallus_gallus GACTCCGGT-TCTATTTTGTTGGTTTTCGGAAACGGGGCCATGATTAAGA 1_Ornithorhynchus_anatinus GACCCCGGTGCCTATTTTGTTGGTTTTCGGAACTGGGGCCATGATTAAGA *** **** ********************* * ************** 2_Mus_musculus GGGACGGCCGGGGGCATTCGTATTGCGCCGCTAGAGGTGAAATTCTTGGA 3_Homo_sapiens GGGACGGCCGGGGGCATTCGTATTGCGCCGCTAGAGGTGAAATTCTTGGA 4_Gallus_gallus GGGACGGCCGGGGGCATTCGTATTGTGCCGCTAGAGGTGAAATTCTTGGA 1_Ornithorhynchus_anatinus GGGACGGCCGGGGGCATTCGTATTGTGCCGCTAGAGGTGAAATTCTTGGA ************************* ************************ 2_Mus_musculus CCGGCGCAAGACGGACCAGAGCGAAAGCATTTGCCAAGAATGTTTTCATT 3_Homo_sapiens CCGGCGCAAGACGGACCAGAGCGAAAGCATTTGCCAAGAATGTTTTCATT 4_Gallus_gallus CCGGCGCAAGACGAACTAAAGCGAAAGCATTTGCCAAGAATGTTTTCATT 1_Ornithorhynchus_anatinus CCGGCGCAAGACGGACCAGAGCGAAAGCATTTGCCAAGAATGTTTTCATT ************* ** * ******************************* 2_Mus_musculus AATCAAGAACGAAAGTCGGAGGTTCGAAGACGATCAGATACCGTCGTAGT 3_Homo_sapiens AATCAAGAACGAAAGTCGGAGGTTCGAAGACGATCAGATACCGTCGTAGT 4_Gallus_gallus AATCAAGAACGAAAGTCGGAGGTTCGAAGACGATCAGATACCGTCGTAGT 1_Ornithorhynchus_anatinus AATCAAGAACGAAAGTCGGAGGTTCGAAGACGATCAGATACCGTCGTAGT ************************************************** 2_Mus_musculus TCCGACCATAAACGATGCCGACTGGCGATGCGGCGGCGTTATTCCCATGA 3_Homo_sapiens TCCGACCATAAACGATGCCGACCGGCGATGCGGCGGCGTTATTCCCATGA 4_Gallus_gallus TCCGACCATAAACGATGCCGACTCGCGATCCGGCGGCGTTATTCCCATGA 1_Ornithorhynchus_anatinus TCCGACCATAAACGATGCCGACTCGCGATCCGGCGGCGTTATTCCCATGA ********************** ***** ******************** 2_Mus_musculus CCCGCCGGGCAGC-TTCCGGGAAACCAAAGTCTTTGGGTTCCGGGGGGAG 3_Homo_sapiens CCCGCCGGGCAGC-TTCCGGGAAACCAAAGTCTTTGGGTTCCGGGGGGAG 4_Gallus_gallus CCCGCCGGGCAGC-TCCCGGGAAACCCAAGTCTTTGGGTTCCGGGGGGAG 1_Ornithorhynchus_anatinus CCCGCCGGGCAGCCTTCCGGGAAACCAAAGTCTTTGGGTTCCGGGGGGAG ************* * ********** *********************** 2_Mus_musculus TATGGTTGCAAAGCTGAAACTTAAAGGAATTGACGGAAGGGCACCACCAG 3_Homo_sapiens TATGGTTGCAAAGCTGAAACTTAAAGGAATTGACGGAAGGGCACCACCAG 4_Gallus_gallus TATGGTTGCAAAGCTGAAACTTAAAGGAATTGACGGAAGGGCACCACCAG 1_Ornithorhynchus_anatinus TATGGTTGCAAAGCTGAAACTTAAAGGAATTGACGGAAGGGCACCACCAG ************************************************** 2_Mus_musculus GAGTGG-GCCTGCGGCTTAATTTGACTCAACACGGGAAACCTCACCCGGC 3_Homo_sapiens GAGTGGAGCCTGCGGCTTAATTTGACTCAACACGGGAAACCTCACCCGGC 4_Gallus_gallus GAGTGGAGCCTGCGGCTTAATTTGACTCAACACGGGAAACCTCACCCGGC 1_Ornithorhynchus_anatinus GAGTGGAGCCTGCGGCTTAATTTGACTCAACACGGGAAACCTCACCCGGC ****** ******************************************* 2_Mus_musculus CCGGACACGGACAGGATTGACAGATTGATAGCTCTTTCTCGATTCCGTGG 3_Homo_sapiens CCGGACACGGACAGGATTGACAGATTGATAGCTCTTTCTCGATTCCGTGG 4_Gallus_gallus CCGGACACGGACAGGATTGACAGATTGAGAGCTCTTTCTCGATTCCGTGG 1_Ornithorhynchus_anatinus CCGGACACGGAAAGGATTGACAGATCGATAGCTCTTTCTCGATTCTGTGG *********** ************* ** **************** **** 2_Mus_musculus GTGGTGGTGCATGGCCGTTCTTAGTTGGTGGAGCGATTTGTCTGGTTAAT 3_Homo_sapiens GTGGTGGTGCATGGCCGTTCTTAGTTGGTGGAGCGATTTGTCTGGTTAAT 4_Gallus_gallus GTGGTGGTGCATGGCCGTTCTTAGTTGGTGGAGCGATTTGTCTGGTTAAT 1_Ornithorhynchus_anatinus GTGGTGGTGCATGGCCGTTCTTAGTTGGTGGAGCGATTTGTCTGGTTAAT ************************************************** 2_Mus_musculus TCCGATAACGAACGAGACTCTGGCATGCTAACTAGTTACGCGACCCCC-G 3_Homo_sapiens TCCGATAACGAACGAGACTCTGGCATGCTAACTAGTTACGCGACCCCC-G 4_Gallus_gallus TCCGATAACGAACGAGACTCTGGCATGCTAACTAGTTACGCGACCCCC-G 1_Ornithorhynchus_anatinus TCCGATAACGAACGAGACTCTGACATGCTAACTAGTTACGCGACCCCCCG ********************** ************************* * 2_Mus_musculus AGCGGTCGGCGTCCCCCAACTTCTTAGAGGGACAAGTGGCGTTCAGCCAC 3_Homo_sapiens AGCGGTCGGCGTCCCCCAACTTCTTAGAGGGACAAGTGGCGTTCAGCCAC 4_Gallus_gallus AGCGGTCGGCGTCC---AACTTCTTAGAGGGACAAGTGGCGTTCAGCCAC 1_Ornithorhynchus_anatinus AGCGGTCGGCGTCC---AACTTCTTAGAGGGACAAGTGGCGTTTAGCCAC ************** ************************** ****** 2_Mus_musculus CCGAGATTGAGCAATAACAGGTCTGTGATGCCCTTAGATGTCCGGGGCTG 3_Homo_sapiens CCGAGATTGAGCAATAACAGGTCTGTGATGCCCTTAGATGTCCGGGGCTG 4_Gallus_gallus CCGAGATTGAGCAATAACAGGTCTGTGATGCCCTTAGATGTCCGGGGCTG 1_Ornithorhynchus_anatinus CCGAGATTGAGCAATAACAGGTCTGTGATGCCCTTAGATGTCCGGGGCTG ************************************************** 2_Mus_musculus CACGCGCGCTACACTGACTGGCTCAGCGTGTGCCTACCCTGCGCCGGCAG 3_Homo_sapiens CACGCGCGCTACACTGACTGGCTCAGCGTGTGCCTACCCTACGCCGGCAG 4_Gallus_gallus CACGCGCGCTACACTGACTGGCTCAGCTTGTGTCTACCCTACGCCGGCAG 1_Ornithorhynchus_anatinus CACGCGCGCTACACTGACTGGCTCAGCGTGTGTCTACCCTCCGCCGACAG *************************** **** ******* ***** *** 2_Mus_musculus GCGCGGGTAACCCGTTGAACCCCATTCGTGATGGGGATCGGGGATTGCAA 3_Homo_sapiens GCGCGGGTAACCCGTTGAACCCCATTCGTGATGGGGATCGGGGATTGCAA 4_Gallus_gallus GCGCGGGTAACCCGTTGAACCCCATTCGTGATGGGGATCGGGGATTGCAA 1_Ornithorhynchus_anatinus GTGCGGGTAACCCGTTGAACCCCATTCGTGATGGGGATCGGGGATTGCAA * ************************************************ 2_Mus_musculus TTATTCCCCATGAACGAGGAATTCCCAGTAAGTGCGGGTCATAAGCTTGC 3_Homo_sapiens TTATTCCCCATGAACGAGGAATTCCCAGTAAGTGCGGGTCATAAGCTTGC 4_Gallus_gallus TTATTCCCCATGAACGAGGAATTCCCAGTAAGTGCGGGTCATAAGCTCGC 1_Ornithorhynchus_anatinus TTATTCCCCATGAACGAGGAATTCCCAGTAAGTGCGGGTCATAAGCTTGC *********************************************** ** 2_Mus_musculus GTTGATTAAGTCCCTGCCCTTTGTACACACCGCCCGTCGCTACTACCGAT 3_Homo_sapiens GTTGATTAAGTCCCTGCCCTTTGTACACACCGCCCGTCGCTACTACCGAT 4_Gallus_gallus GTTGATTAAGTCCCTGCCCTTTGTACACACCGCCCGTCGCTACTACCGAT 1_Ornithorhynchus_anatinus GTTGATTAAGTCCCTGCCCTTTGTACACACCGCCCGTCGCTACTACCGAT ************************************************** 2_Mus_musculus TGGATGGTTTAGTGAGGCCCTCGGATCGGCCCCGCCGGGGTCGGCCCACG 3_Homo_sapiens TGGATGGTTTAGTGAGGCCCTCGGATCGGCCCCGCCGGGGTCGGCCCACG 4_Gallus_gallus TGGATGGTTTAGTGAGGTCCTCGGATCGGCCCCGGCGGGGTCGGCC-ACG 1_Ornithorhynchus_anatinus TGGATGGTTTAGTGAGGTCCTCGGATCGGCCCCGCCGGGGGTCGGCCACG ***************** **************** ***** * * *** 2_Mus_musculus GCCC-TGGCGGAGCGCTGAGAAGACGGTCGAACTTGACTATCTAGAGGAA 3_Homo_sapiens GCC--TGGCGGAGCGCTGAGAAGACGGTCGAACTTGACTATCTAGAGGAA 4_Gallus_gallus GCCC-TGCCGGAGCGTCGAGAAGACGGTCGAACTTGACTATCTAGAGGAA 1_Ornithorhynchus_anatinus GCCCCTGGCGGAGCGCTGAGAAGACGGTCGAACTTGACTATCTAGAGGAA *** ** ******* ********************************* 2_Mus_musculus GTAAAAGTCGTAACAAGGTTTCCGTAGGTGAACCTGCGGAAGGATCATTA 3_Homo_sapiens GTAAAAGTCGTAACAAGGTTTCCGTAGGTGAACCTGCGGAAGGATCATTA 4_Gallus_gallus GTAAA--------------------------------------------- 1_Ornithorhynchus_anatinus GTAAAAGTCGTAACAAGGTTTCCGTAG----------------------- *****